Magnify Biosciences, Inc. – Visualize the Future of Precision Medicine

Magnify is a sample preparation technique that enhances light microscope resolution beyond the diffraction limit to expand the scope of research.

Using only a light microscope, Magnify enables rapid, low-cost 3D nanoscale imaging of DNA, RNA, proteins, lipids, and sugars with universal anchoring in any tissue, paving the way for scalable, accurate 3D multi-modal imaging.

Magnify enables imaging of tens of biomarkers in the nanoscale, visualizing previously inaccessible complex protein interactions and their change in response to the drug.

Magnify revolutionizes neural research by enabling rapid 3D mapping of synapses, providing detailed structure and molecular insights without the need for traditional, labor-intensive 2D layering techniques using electron microscopes.

Magnify protocol has been validated on human FFPE biopsies on the breast, uterus, placenta, thymus, thyroid, etc, to reveal the previously unachievable resolution using only a light microscope.

Magnify enables nanoscale 3D imaging of pathogens (0.5-5 microns, yellow) on challenging, collagen-rich keratitis human cornea tissues (purple) with enough resolution to distinguish subtle morphology differences.

Illuminating the path to precision medicine with beyond-limit imaging.

Magnify transforms a conventional light microscope to rapidly achieve 3-dimensional nanoscale structural and molecular imaging of DNA, RNA, proteins, lipids, and sugars in any tissue with high precision, enabling scalable, comprehensive imaging.

Our Product

Magnify Biosciences provides a user-friendly, rapid imaging kit that preserves a wide range of biomolecules, accelerates tissue expansion, and is compatible with multiple organ types, revolutionizing nanoscale analysis in biological research and industry applications.

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Our Service

Magnify Biosciences provides comprehensive services from specimen prep to nanoimaging analysis, aiding drug development and disease research with our Magnify-validated antibodies and expertise, delivering nanoscale insights swiftly and precisely.

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Publications

Z. Cheng, C. Stefani, T. Skillman, A. Klimas, A. Lee, E. DiBernardo, K. Brown, T. Milman, Y. Wang, B. Gallagher, K. Lagree, B. Jena, J. Pulido, A. Mitchell, S. Filler, L. Hiller, A. Lacy-Hulbert, Y. Zhao*, “MicroMagnify: a multiplexed expansion microscopy method for pathogens and infected tissues”, Advanced Science, 2023, 2302249.

[Cover Article] A. Klimas, B. Gallagher, P. Wijesekara, S. Fekir, E. F. DiBernardo, Z. Cheng, D. Stolz, F. Cambi, S. Watkins, S. L. Brody, A. Horani, A. L. Barth, C. Moore, X. Ren, Y. Zhao*, “Magnify is a universal molecular anchoring strategy for expansion microscopy”.Nature Biotechnology 41, pages 858–869 (2023).

F. Han, S. Gu, A. Klimas, N. Zhao, Y. Zhao* (co-corresponding), S-C, Chen*, “Three-dimensional nanofabrication via ultrafast laser patterning and kinetically regulated material assembly”, Science, 2022, 378, 6626

L. Shi, A. Klimas, B. Gallagher, Z. Cheng, F. Fu, P. Wijesekara, Y. Miao, X. Ren, Y Zhao* (co-corresponding author), W Min*, “Super-resolution vibrational imaging using expansion stimulated Raman scattering microscopy”, Advanced Science,2022, 2200315.